Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer

• Main Authors: Lim, Shu Wen, Tan, Jun Kai, Osman, Mohd Azuraidi, Sathiya, Maran, Lim, Ee Chen, Lai, Kok Song, Yap, Wai Sum, Nik Abd Rahman, Nik Mohd Afizan
• Format: Article
• Language: English
• Published: Nature Publishing 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/97399/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/97399/; https://www.nature.com/articles/s41598-021-03624-x

MYB proteins are highly conserved DNA-binding domains (DBD) and mutations in MYB oncoproteins have been reported to cause aberrant and augmented cancer progression. Identification of MYB molecular biomarkers predictive of cancer progression can be used for improving cancer management. To address thi...