Dual activity bleg-1 from Bacillus Lehensis g1 revealed structural resemblance to b3 metallo-β-lactamase and glyoxalase ii: An insight into its enzyme promiscuity and evolutionary divergence

• Main Authors: Au, Shaw Xian, Dzulkifly, Nur Syazana, Muhd Noor, Noor Dina, Matsumura, Hiroyoshi, Raja Abdul Rahman, Raja Noor Zaliha, Mohd Yahaya, Normi
• Format: Article
• Published: Multidisciplinary Digital Publishing Institute 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/96804/; https://www.mdpi.com/1422-0067/22/17/9377

Metallo-β-lactamases (MBLs) are class B β-lactamases from the metallo-hydrolase-like MBL-fold superfamily which act on a broad range of β-lactam antibiotics. A previous study on BLEG-1 (formerly called Bleg1_2437), a hypothetical protein from Bacillus lehensis G1, revealed sequence similarity and ac...