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Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives

Pursuing our interest in bioactive heterocyclic compound, two benzoimidazoquinazoline derivatives were synthesised using both microwave-assisted and classical heating methods. Structures of the compounds were confirmed by standard spectroscopic methods and elemental analysis. The target scaffolds we...

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Main Authors: Ali Hasan, Hiba, Salman, Afrah, Abdulmalek, Emilia
Format: Article
Published: A and V Publication 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95899/
https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-7
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spelling my.upm.eprints.958992023-03-24T08:09:30Z http://psasir.upm.edu.my/id/eprint/95899/ Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives Ali Hasan, Hiba Salman, Afrah Abdulmalek, Emilia Pursuing our interest in bioactive heterocyclic compound, two benzoimidazoquinazoline derivatives were synthesised using both microwave-assisted and classical heating methods. Structures of the compounds were confirmed by standard spectroscopic methods and elemental analysis. The target scaffolds were incidentally found to emit blue light when exposed to ultraviolet light. Consequently, a photoluminescence characterization was carried out as a part of characterization protocol. The anticancer activities of the benzimidazoquinazoline compounds were investigated using both methylthiazol tetrazolium (MTT) and the high content screen (HCS) assays against liver hepatocellular cells. The results showed a significant reduction in the inhibitory concentration of the cancer cells by 1 and 2.6 fold when exposed to compounds (3a) and (3b), respectively. The high content screen (HCS) was conducted for compound (3b) and the results showed high toxicity towards the cancer cells. A and V Publication 2021 Article PeerReviewed Ali Hasan, Hiba and Salman, Afrah and Abdulmalek, Emilia (2021) Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives. Research Journal of Pharmacy and Technology, 14 (5). 2397 - 2405. ISSN 0974-3618; ESSN: 0974-360X https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-7 10.52711/0974-360X.2021.00423
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Pursuing our interest in bioactive heterocyclic compound, two benzoimidazoquinazoline derivatives were synthesised using both microwave-assisted and classical heating methods. Structures of the compounds were confirmed by standard spectroscopic methods and elemental analysis. The target scaffolds were incidentally found to emit blue light when exposed to ultraviolet light. Consequently, a photoluminescence characterization was carried out as a part of characterization protocol. The anticancer activities of the benzimidazoquinazoline compounds were investigated using both methylthiazol tetrazolium (MTT) and the high content screen (HCS) assays against liver hepatocellular cells. The results showed a significant reduction in the inhibitory concentration of the cancer cells by 1 and 2.6 fold when exposed to compounds (3a) and (3b), respectively. The high content screen (HCS) was conducted for compound (3b) and the results showed high toxicity towards the cancer cells.
format Article
author Ali Hasan, Hiba
Salman, Afrah
Abdulmalek, Emilia
spellingShingle Ali Hasan, Hiba
Salman, Afrah
Abdulmalek, Emilia
Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives
author_facet Ali Hasan, Hiba
Salman, Afrah
Abdulmalek, Emilia
author_sort Ali Hasan, Hiba
title Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives
title_short Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives
title_full Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives
title_fullStr Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives
title_full_unstemmed Anticancer activity and high content screening of New 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives
title_sort anticancer activity and high content screening of new 6 substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives
publisher A and V Publication
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95899/
https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-7
_version_ 1761620397965443072
score 13.18916

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