Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach
Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a prom...
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my.upm.eprints.958882023-03-24T07:39:35Z http://psasir.upm.edu.my/id/eprint/95888/ Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach Ranneh, Yazan Abu Bakar, Mohd Fadzelly Ismail, Nur Amalina Kormin, Faridah Mohamed, Maryati Md Akim, Abdah Isha, Azizul Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a promising approach to alleviate aging process and prevent Alzheimer. The aim of the current investigation was to optimize a novel anti-aging formulation from traditional plants (Cnestis palala stem, Urceola micrantha stem, Marantodes pumilum stem and Microporus xanthopus fruiting bodies) using simplex centroid mixture design (SCMD). After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTṠ+ and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of C. palala, U. micrantha and the binary mixture of C. palala and U. micrantha were the optimal formulations with high antioxidant activities. Single extract of U. micrantha showed the highest inhibition towards matrix metalloproteinase-1 (49.44 ± 4.11 %), while C. palala water extract showed highest inhibitions towards tyrosinase (14.06 ± 0.31%), acetylcholinesterase (32.92 ± 2.13%) and butyrylcholinesterase (34.89 ± 2.84%) enzymes. The single extracts of C. palala and U. micrantha displayed better activity as compared to the binary mixture formulation. In conclusion, these findings could be a baseline for further exploration of novel anti-aging agents from natural resources. Elsevier 2021 Article PeerReviewed Ranneh, Yazan and Abu Bakar, Mohd Fadzelly and Ismail, Nur Amalina and Kormin, Faridah and Mohamed, Maryati and Md Akim, Abdah and Isha, Azizul (2021) Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach. Saudi Journal of Biological Sciences, 28 (12). pp. 6711-6720. ISSN 1319-562X https://www.sciencedirect.com/science/article/pii/S1319562X21006306 10.1016/j.sjbs.2021.07.048 |
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Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a promising approach to alleviate aging process and prevent Alzheimer. The aim of the current investigation was to optimize a novel anti-aging formulation from traditional plants (Cnestis palala stem, Urceola micrantha stem, Marantodes pumilum stem and Microporus xanthopus fruiting bodies) using simplex centroid mixture design (SCMD). After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTṠ+ and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of C. palala, U. micrantha and the binary mixture of C. palala and U. micrantha were the optimal formulations with high antioxidant activities. Single extract of U. micrantha showed the highest inhibition towards matrix metalloproteinase-1 (49.44 ± 4.11 %), while C. palala water extract showed highest inhibitions towards tyrosinase (14.06 ± 0.31%), acetylcholinesterase (32.92 ± 2.13%) and butyrylcholinesterase (34.89 ± 2.84%) enzymes. The single extracts of C. palala and U. micrantha displayed better activity as compared to the binary mixture formulation. In conclusion, these findings could be a baseline for further exploration of novel anti-aging agents from natural resources. |
format |
Article |
author |
Ranneh, Yazan Abu Bakar, Mohd Fadzelly Ismail, Nur Amalina Kormin, Faridah Mohamed, Maryati Md Akim, Abdah Isha, Azizul |
spellingShingle |
Ranneh, Yazan Abu Bakar, Mohd Fadzelly Ismail, Nur Amalina Kormin, Faridah Mohamed, Maryati Md Akim, Abdah Isha, Azizul Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach |
author_facet |
Ranneh, Yazan Abu Bakar, Mohd Fadzelly Ismail, Nur Amalina Kormin, Faridah Mohamed, Maryati Md Akim, Abdah Isha, Azizul |
author_sort |
Ranneh, Yazan |
title |
Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach |
title_short |
Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach |
title_full |
Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach |
title_fullStr |
Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach |
title_full_unstemmed |
Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach |
title_sort |
anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach |
publisher |
Elsevier |
publishDate |
2021 |
url |
http://psasir.upm.edu.my/id/eprint/95888/ https://www.sciencedirect.com/science/article/pii/S1319562X21006306 |
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1761620397254508544 |
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13.211869 |