The effects of intravenous infusion of autologous mesenchymal stromal cells in patients with subacute middle cerebral artery infarct: a phase 2 randomized controlled trial on safety, tolerability and efficacy

• Main Authors: Zhe, Kang Law, Hui, Jan Tan, Sze, Piaw Chin, Chee, Yin Wong, Wan Yahya, Wan Nur Nafisah, Muda, Ahmad Sobri, Zakaria, Rozman, Ariff, Mohd Izhar, Ismail, Nor Azimah, Soon, Keng Cheong, S. Abdul Wahid, S. Fadilah, Mohamed Ibrahim, Norlinah
• Format: Article
• Language: English
• Published: Elsevier 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/95417/1/The%20effects%20of%20intravenous%20infusion%20of%20autologous%20mesenchymal%20stromal%20cells%20in%20patients%20with%20subacute%20middle%20cerebral%20artery%20infarct%20a%20phase%202%20randomized%20controlled%20trial%20on%20safety%2C%20tolerability%20and%20efficacy.pdf; http://psasir.upm.edu.my/id/eprint/95417/; https://www.sciencedirect.com/science/article/pii/S1465324921002140

Background aims Mesenchymal stromal cells (MSCs) are characterized by paracrine and immunomodulatory functions capable of changing the microenvironment of damaged brain tissue toward a more regenerative and less inflammatory milieu. The authors conducted a phase 2, single-center, assessor-blinded ra...