Systematic review and meta-analyses of vitamin E alpha-tocopherol supplementation and blood lipid parameters in patients with diabetes mellitus

• Main Authors: Mohammad, Abolfathi, Falahi, Ebrahim, Mohd Yusof, Barakatun Nisak, Nor Hanipah, Zubaidah, S., Mohd Redzwan, Mohamad Yusof, Loqman, Gheitasvand, Mohsen, Rezaie, Farahnaz
• Format: Article
• Published: Elsevier 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/95278/; https://www.sciencedirect.com/science/article/pii/S1871402121001752

Background and aims: The studies have shown that α-tocopherol supplementation could improve lipid profile in diabetes mellitus (DM) patients. Nonetheless, the result remains inconsistent. Therefore, this meta-analysis was performed to evaluate the efficacy of α-tocopherol supplement on lipid parameters in DM patients. Methods: We conducted an extensive search via Cochrane Library, PubMed, Scopus, and Web of Science databases to acquire the reported RCTs up to October 2020. Results: The results showed no effects of α-tocopherol supplementation on lipid profile in DM patients except when used ≥12 weeks. Conclusions: α-tocopherol supplementation in DM patients had no significant effect on lipid profiles.