Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines

• Main Authors: Khor, Poh Yen, Stanslas, Johnson, Zhang, Tianshu, Li, Hongyuan, Wang, Xiaohui, Chan, Kok Meng, Lam, Kok Wai
• Format: Article
• Published: Elsevier 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/95274/; https://www.sciencedirect.com/science/article/pii/S0968089621004508?via%3Dihub

Acquired paclitaxel (PTX) chemoresistance in triple-negative breast cancer (TNBC) can be inferred from the overexpression of toll-like receptor 4 (TLR4) and myeloid differentiation primary response 88 (MyD88) proteins and the activation of the TLR4/MyD88 cascading signalling pathway. Finding a new i...