Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes

• Main Authors: Hassan, Hishar, Othman, Muhammad Faiz, Abdul Razak, Hairil Rashmizal
• Format: Article
• Published: De Gruyter 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/94441/; https://www.degruyter.com/document/doi/10.1515/ract-2021-1024/html

18F-fluorination using aluminum-fluoride ([18F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation of [18F]AlF2+ and [18F]AlF-NOTA-NHS complex with the radiochemical yield (RCY) and purity (RCP) of more than 90% as a prerequisite step before proceeding with the radiopharmaceutical preparation using the [18F]AlF-bifunctional chelator technique. As well as being simple, the suggested method is practical and relevant for beginners interested in 18F-fluorination with [18F]AlF-chelate complex technique or also for a researcher who aims to proceed on an extensive scale.