Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study
Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury A...
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2021
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Online Access: | http://psasir.upm.edu.my/id/eprint/90341/1/2021040610445401_MJMHS_0348.pdf http://psasir.upm.edu.my/id/eprint/90341/ https://medic.upm.edu.my/upload/dokumen/2021040610445401_MJMHS_0348.pdf |
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my.upm.eprints.903412021-09-09T23:43:28Z http://psasir.upm.edu.my/id/eprint/90341/ Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale (ASIA-AIS) D patients using proton magnetic resonance spectroscopy or 1 H-MRS. Methods: These metabolites were measured from the vastus lateralis and semitendinosus muscles of three incomplete SCI ASIA-AIS D patients who completed the FES exercise and later underwent 3 Tesla (T) MRI (repetition time/echo time; TR/TE of 3500ms/100ms, field-ofview; FOV of 20cm, slice thickness of 6mm) and 1 H-MRS (TR/TE of 2000ms/31ms, voxel size of 20mm x 20mm x 35mm). Results: Out of those selected metabolites, only CHO value of vastus lateralis showed a statistically significant difference between pre- and post FES exercise 1 H-MRS scanning (p = 0.01). Conclusion: Therefore, this preliminary finding has postulated that the quantification of muscle metabolites using 1 H-MRS imaging could be used as a potential indicator in evaluating the muscle strength for incomplete SCI ASIA-AIS D patients after the completion of FES cycling exercise. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2021-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90341/1/2021040610445401_MJMHS_0348.pdf Rusli, Nur Syahfinaz Hidayah and Zakaria, Faikah and Abdul Razak, Hairil Rashmizal (2021) Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study. Malaysian Journal of Medicine and Health Sciences, 17 (2). pp. 4-10. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2021040610445401_MJMHS_0348.pdf |
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Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale (ASIA-AIS) D patients using proton magnetic resonance spectroscopy or 1 H-MRS. Methods: These metabolites were measured from the vastus lateralis and semitendinosus muscles of three incomplete SCI ASIA-AIS D patients who completed the FES exercise and later underwent 3 Tesla (T) MRI (repetition time/echo time; TR/TE of 3500ms/100ms, field-ofview; FOV of 20cm, slice thickness of 6mm) and 1 H-MRS (TR/TE of 2000ms/31ms, voxel size of 20mm x 20mm x 35mm). Results: Out of those selected metabolites, only CHO value of vastus lateralis showed a statistically significant difference between pre- and post FES exercise 1 H-MRS scanning (p = 0.01). Conclusion: Therefore, this preliminary finding has postulated that the quantification of muscle metabolites using 1 H-MRS imaging could be used as a potential indicator in evaluating the muscle strength for incomplete SCI ASIA-AIS D patients after the completion of FES cycling exercise. |
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Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal |
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Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study |
author_facet |
Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal |
author_sort |
Rusli, Nur Syahfinaz Hidayah |
title |
Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study |
title_short |
Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study |
title_full |
Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study |
title_fullStr |
Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study |
title_full_unstemmed |
Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study |
title_sort |
quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 h-mrs) for incomplete spinal cord injury patients: preliminary study |
publisher |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
publishDate |
2021 |
url |
http://psasir.upm.edu.my/id/eprint/90341/1/2021040610445401_MJMHS_0348.pdf http://psasir.upm.edu.my/id/eprint/90341/ https://medic.upm.edu.my/upload/dokumen/2021040610445401_MJMHS_0348.pdf |
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