In-vitro and in-silico evaluations of heterocyclic-containing diarylpentanoids as Bcl-2 inhibitors against LoVo colorectal cancer cells

• Main Authors: Leong, Sze Wei, Chia, Suet Lin, Abas, Faridah, Yusoff, Khatijah
• Format: Article
• Language: English
• Published: Multidisciplinary Digital Publishing Institute 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/89458/1/LOVO.pdf; http://psasir.upm.edu.my/id/eprint/89458/; https://www.mdpi.com/1420-3049/25/17/3877

In the present study, we investigated the in-vitro anti-cancer potential of six diarylpentanoids against a panel of BRAF- and KRAS-mutated colorectal cancer cell lines including T84, SW620, LoVo, HT29, NCI-H508, RKO, and LS411N cells. Structure-activity relationship study suggested that the insertio...