Identification of potential chemical substrates as fuel for hypoxic tumors that may be linked to invadopodium formation in hypoxia-induced MDA-MB-231 breast-cancer cell line

• Main Authors: Hamad, Hamad Ali, Enezei, Hamid Hammad, Alrawas, Anmar, Muhamad Zakuan, Noraina, Abdullah, Nurul Akmaryanti, Yoke, Kqueen Cheah, Md Hashim, Nur Fariesha
• Format: Article
• Language: English
• Published: Multidisciplinary Digital Publishing Institute 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/89256/1/CANCER.pdf; http://psasir.upm.edu.my/id/eprint/89256/; https://www.mdpi.com/1420-3049/25/17/3876

Hypoxia plays a significant role in solid tumors by the increased expression of hypoxia-inducible factor-1α (HIF-1α), which is known to promote cancer invasion and metastasis. Cancer-cell invasion dynamically begins with the degradation of the extracellular matrix (ECM) via invadopodia formation. Th...