Hypoxic-mediated oxidative stress condition and hydroxyapatite-inducing osteogenic differentiation of human mesenchymal stem cells: a mathematical modelling study

• Main Authors: Cui, Yan Chao, Qiu, Yu Sheng, Wu, Qiong, Bu, Gang, Seoh, Wei Teh, Guo, Zhong He, Pooi, Ling Mok, Samrot, Anthony V., Mariappan, Rajan, Higuchi, Akon, Arulselvan, Palanisamy, Rampal, Sanjiv Rampal Lekhraj, Muthuvenkatachalam, Bala Sundaram, K.B., Swamy, Sun, Zhong, Kok, Pian Ang, Kong, Yong Then, Kumar, S. Suresh
• Format: Article
• Language: English
• Published: American Scientific Publishers 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/89244/1/STEM.pdf; http://psasir.upm.edu.my/id/eprint/89244/; https://www.ingentaconnect.com/content/asp/jbn/2020/00000016/00000006/art00012;jsessionid=497n9ge0gmtrk.x-ic-live-02

Avascular necrosis (AVN) of the bones remains a major clinical challenge. Fractures in the talus, the scaphoid, and the neck of the femur are especially challenging to heal due to the low blood vessel network and the lack of collateral blood supply. These fractures are associated with high rates of...