Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

• Main Authors: Abdullah, Rozaini, Wesseling, Sebastiaan, Spenkelink, Bert, Louisse, Jochem, Punt, Ans, Rietjens, Ivonne M. C. M.
• Format: Article
• Language: English
• Published: John Wiley & Sons 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/88350/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/88350/; https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.4024

Aristolochic acid I (AAI) is a well-known genotoxic kidney carcinogen. Metabolic conversion of AAI into the DNA-reactive aristolactam-nitrenium ion is involved in the mode of action of tumor formation. This study aims to predict in vivo AAI-DNA adduct formation in the kidney of rat, mouse and human...