Multiple gene targeting siRNAs for down regulation of Immediate Early-2 (Ie2) and DNA polymerase genes mediated inhibition of novel rat Cytomegalovirus (strain All-03)

• Main Authors: Balakrishnan, Krishnan Nair, Abdullah, Ashwaq Ahmed, Bala, Jamilu Abubakar, Abdullah, Faez Firdaus Jesse, Che Abdullah, Che Azurahanim, Mohamed Noordin, Mustapha, Mohd Azmi, Mohd Lila
• Format: Article
• Language: English
• Published: Springer 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/86859/1/Multiple%20gene%20targeting%20siRNAs%20for%20down%20regulation%20of%20Immediate%20Early.pdf; http://psasir.upm.edu.my/id/eprint/86859/; https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01436-5

Background: Cytomegalovirus (CMV) is an opportunistic pathogen that causes severe complications in congenitally infected newborns and non-immunocompetent individuals. Developing an effective vaccine is a major public health priority and current drugs are fronting resistance and side effects on recip...