Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells
The present study deals with Plectranthus amboinicus (Lour.), multiple potential herbs perceived as a medicinal and culinary adjunct has been used to fabricate gold (Au) nanoparticles (NPs) in an eco-benign fashion. We have primly reported the antioxidant and anticarcinogenic effects of phytofabrica...
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Taylor & Francis
2020
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Online Access: | http://psasir.upm.edu.my/id/eprint/86708/1/Mechanistic%20anticarcinogenic%20efficacy%20of%20phytofabricated%20gold%20nanoparticles%20.pdf http://psasir.upm.edu.my/id/eprint/86708/ https://www.tandfonline.com/doi/full/10.1080/17458080.2020.1761014 |
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my.upm.eprints.867082021-11-09T07:57:30Z http://psasir.upm.edu.my/id/eprint/86708/ Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells Suresh, Sagadevan Muthukrishnan, Lakshmipathy Vennila, Selvaraj K., Gurunathan Lett J., Anita Paiman, Suriati Mohammad Faruq Al-Lohedan, Hamad A. Akbarzadeh, Omid Won, Chun Oh The present study deals with Plectranthus amboinicus (Lour.), multiple potential herbs perceived as a medicinal and culinary adjunct has been used to fabricate gold (Au) nanoparticles (NPs) in an eco-benign fashion. We have primly reported the antioxidant and anticarcinogenic effects of phytofabricated Au NPs towards lung adenocarcinoma (LAC) cells (A549 cell line) in vitro. The herbal concentrate, size and dosage of Au NPs were the key variables that determined the anticarcinogenic efficacy. Results indicated that the herbal concentrate encompassing flavonoids, alkaloids and polyphenolics aided reduction and stabilisation of Au NPs supported by spectral (λmax @ 550 nm) and quantitative analyses. The Fourier transform-infrared spectra anticipated distinct phenolics and protein frequencies involved in Au NPs capping in the course of fabrication. The manipulated Au NPs of 15 nm size has significantly influenced the radical scavenging (48.1 μg) and proliferation pattern of LAC cells (A549) associated with cytotoxic characteristics and IC50 (Au NPs concentration linked with 50% mortality) defined at 16.3 μg/mL in 48 h. This nanotoxicological prospect on the use of nanomaterials as an anticancer agent would be an alternative for the emerging intrinsic resistance of cells to the drug; a great challenge pertaining to safer environmental and biological outcomes. Taylor & Francis 2020-05 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86708/1/Mechanistic%20anticarcinogenic%20efficacy%20of%20phytofabricated%20gold%20nanoparticles%20.pdf Suresh, Sagadevan and Muthukrishnan, Lakshmipathy and Vennila, Selvaraj and K., Gurunathan and Lett J., Anita and Paiman, Suriati and Mohammad Faruq and Al-Lohedan, Hamad A. and Akbarzadeh, Omid and Won, Chun Oh (2020) Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells. Journal of Experimental Nanoscience, 15 (1). 160 - 173. ISSN 1745-8080; ESSN: 1745-8099 https://www.tandfonline.com/doi/full/10.1080/17458080.2020.1761014 10.1080/17458080.2020.1761014 |
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The present study deals with Plectranthus amboinicus (Lour.), multiple potential herbs perceived as a medicinal and culinary adjunct has been used to fabricate gold (Au) nanoparticles (NPs) in an eco-benign fashion. We have primly reported the antioxidant and anticarcinogenic effects of phytofabricated Au NPs towards lung adenocarcinoma (LAC) cells (A549 cell line) in vitro. The herbal concentrate, size and dosage of Au NPs were the key variables that determined the anticarcinogenic efficacy. Results indicated that the herbal concentrate encompassing flavonoids, alkaloids and polyphenolics aided reduction and stabilisation of Au NPs supported by spectral (λmax @ 550 nm) and quantitative analyses. The Fourier transform-infrared spectra anticipated distinct phenolics and protein frequencies involved in Au NPs capping in the course of fabrication. The manipulated Au NPs of 15 nm size has significantly influenced the radical scavenging (48.1 μg) and proliferation pattern of LAC cells (A549) associated with cytotoxic characteristics and IC50 (Au NPs concentration linked with 50% mortality) defined at 16.3 μg/mL in 48 h. This nanotoxicological prospect on the use of nanomaterials as an anticancer agent would be an alternative for the emerging intrinsic resistance of cells to the drug; a great challenge pertaining to safer environmental and biological outcomes. |
format |
Article |
author |
Suresh, Sagadevan Muthukrishnan, Lakshmipathy Vennila, Selvaraj K., Gurunathan Lett J., Anita Paiman, Suriati Mohammad Faruq Al-Lohedan, Hamad A. Akbarzadeh, Omid Won, Chun Oh |
spellingShingle |
Suresh, Sagadevan Muthukrishnan, Lakshmipathy Vennila, Selvaraj K., Gurunathan Lett J., Anita Paiman, Suriati Mohammad Faruq Al-Lohedan, Hamad A. Akbarzadeh, Omid Won, Chun Oh Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells |
author_facet |
Suresh, Sagadevan Muthukrishnan, Lakshmipathy Vennila, Selvaraj K., Gurunathan Lett J., Anita Paiman, Suriati Mohammad Faruq Al-Lohedan, Hamad A. Akbarzadeh, Omid Won, Chun Oh |
author_sort |
Suresh, Sagadevan |
title |
Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells |
title_short |
Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells |
title_full |
Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells |
title_fullStr |
Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells |
title_full_unstemmed |
Mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells |
title_sort |
mechanistic anticarcinogenic efficacy of phytofabricated gold nanoparticles on human lung adenocarcinoma cells |
publisher |
Taylor & Francis |
publishDate |
2020 |
url |
http://psasir.upm.edu.my/id/eprint/86708/1/Mechanistic%20anticarcinogenic%20efficacy%20of%20phytofabricated%20gold%20nanoparticles%20.pdf http://psasir.upm.edu.my/id/eprint/86708/ https://www.tandfonline.com/doi/full/10.1080/17458080.2020.1761014 |
_version_ |
1717095381590867968 |
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13.18916 |