Lipase-catalysed synthesis of a novel galanthamine derivative: process optimisation by artificial neural networks

• Main Authors: Ashari, Siti Efliza, Abdul Karim, Nurul Hidayu, Khairudin, Nur Shafira, Syed Azhar, Sharifah Nurfadhlin Afifah
• Format: Article
• Language: English
• Published: Elsevier 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/86580/1/Lipase-catalysed%20synthesis.pdf; http://psasir.upm.edu.my/id/eprint/86580/; https://www.sciencedirect.com/science/article/abs/pii/S0022286020300855?via%3Dihub

Artificial neural networks (ANNs) analysis was carried out to optimize the esterification of galanthamine and acetic acid in a solvent system. To predict performance parameters of the enzymatic reaction conditions, several parameters were studied which were reaction temperature (50–90 °C), enzyme am...