Role of polymers as crystal growth inhibitors in coprecipitation via solutionenhanced dispersion by supercritical fluids (SEDS) to improve andrographolide dissolution from standardized Andrographis paniculata extract

• Main Authors: Lee, Sin Yee, Abdullah, Luqman Chuah, Abdul Rahman, Russly, Abas, Faridah, Chong, Gun Hean
• Format: Article
• Language: English
• Published: Elsevier 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/82045/1/Role%20of%20polymers%20as%20crystal%20growth%20inhibitors%20.pdf; http://psasir.upm.edu.my/id/eprint/82045/; https://www.sciencedirect.com/science/article/abs/pii/S1773224718311109

The poor aqueous solubility and dissolution rate of andrographolide in aqueous gastrointestinal fluids often cause low oral bioavailability. In this work, Andrographis paniculata extract containing 16% andrographolide was coprecipitated with Pluronic F127, Eudragit EPO, and Eudragit L100-55 via solu...