Methods for systematic identification of membrane proteins for specific capture of cancer-derived extracellular vesicles

• Main Authors: Zaborowsk, Mikołaj Piotr, Lee, Kyungheon, Na, Young Jeong, Sammarco, Alessandro, Zhang, Xuan, Iwanicki, Marcin, Cheah, Pike See, Lin, Hsing-Ying, Zinter, Max, Chou, Chung-Yu, Fulci, Giulia, Tannous, Bakhos A., Lai, Charles Pin-Kuang, Birrer, Michael J., Weissleder, Ralph, Lee, Hakho, Breakefield, Xandra O.
• Format: Article
• Language: English
• Published: Cell Press 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/81345/1/CANCER.pdf; http://psasir.upm.edu.my/id/eprint/81345/; https://www.sciencedirect.com/science/article/pii/S2211124719303109

Analysis of cancer-derived extracellular vesicles (EVs) in biofluids potentially provides a source of disease biomarkers. At present there is no procedure to systematically identify which antigens should be targeted to differentiate cancer-derived from normal host cell-derived EVs. Here, we propose...