Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles
Orotic acid (OA) nanoparticles were prepared using the freeze-drying method. The antihypertensive activity and antioxidant capacity of OA and orotic acid-loaded gum arabic nanoparticles (OAGANPs) were examined using the angiotensin-converting enzyme (ACE), 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitri...
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my.upm.eprints.806822021-04-15T04:44:15Z http://psasir.upm.edu.my/id/eprint/80682/ Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita Orotic acid (OA) nanoparticles were prepared using the freeze-drying method. The antihypertensive activity and antioxidant capacity of OA and orotic acid-loaded gum arabic nanoparticles (OAGANPs) were examined using the angiotensin-converting enzyme (ACE), 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), and β-carotene assays, as well as the quantification of total phenolic content (TPC). The DPPH and NO scavenging activities of OAGANPs were significantly higher than those of the OA solution. The β-carotene bleaching assay of OAGANPs showed a dose-dependent trend, while 500 μg/ml was significantly more effective than the other concentrations, which exerted 63.4% of the antioxidant activity. The in vitro antihypertensive assay revealed that the OAGANPs exhibited the most potent ACE inhibition activity, when compared to the OA solution. Hence, results revealed the potential of preparing the OA as a nanoparticle formulation in enhancing the antioxidant and antihypertensive properties compared to the OA solution. Springer 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80682/1/ACE.pdf Abdelkader, Hassani and Hussain, Siti Aslina and Abdullah, Norhafizah and Kamarudin, Suryani and Rosli, Rozita (2019) Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles. AAPS PharmSciTech, 20 (2). art. no. 53. pp. 1-9. ISSN 1530-9932 https://pubmed.ncbi.nlm.nih.gov/30617521/ 10.1208/s12249-018-1238-2 |
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Orotic acid (OA) nanoparticles were prepared using the freeze-drying method. The antihypertensive activity and antioxidant capacity of OA and orotic acid-loaded gum arabic nanoparticles (OAGANPs) were examined using the angiotensin-converting enzyme (ACE), 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), and β-carotene assays, as well as the quantification of total phenolic content (TPC). The DPPH and NO scavenging activities of OAGANPs were significantly higher than those of the OA solution. The β-carotene bleaching assay of OAGANPs showed a dose-dependent trend, while 500 μg/ml was significantly more effective than the other concentrations, which exerted 63.4% of the antioxidant activity. The in vitro antihypertensive assay revealed that the OAGANPs exhibited the most potent ACE inhibition activity, when compared to the OA solution. Hence, results revealed the potential of preparing the OA as a nanoparticle formulation in enhancing the antioxidant and antihypertensive properties compared to the OA solution. |
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Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita |
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Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles |
author_facet |
Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita |
author_sort |
Abdelkader, Hassani |
title |
Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles |
title_short |
Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles |
title_full |
Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles |
title_fullStr |
Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles |
title_full_unstemmed |
Antioxidant potential and Angiotensin-Converting Enzyme (ACE) inhibitory activity of orotic acid-loaded gum arabic nanoparticles |
title_sort |
antioxidant potential and angiotensin-converting enzyme (ace) inhibitory activity of orotic acid-loaded gum arabic nanoparticles |
publisher |
Springer |
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2019 |
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http://psasir.upm.edu.my/id/eprint/80682/1/ACE.pdf http://psasir.upm.edu.my/id/eprint/80682/ https://pubmed.ncbi.nlm.nih.gov/30617521/ |
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