Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system

The stepping forces of normal and Freund Complete Adjuvant (FCA)-induced arthritic rats were studied in vivo using a proposed novel analgesic meter. An infrared charge-coupled device (CCD) camera and a data acquisition system were incorporated into the analgesic meter to determine and measure the we...

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Main Authors: Yam, Mun Fei, Ahmad, Mariam, Por, Lip Yee, Ang, Lee Fung, Basir, Rusliza, Asmawi, Mohd Zaini
Format: Article
Language:English
Published: MDPI 2012
Online Access:http://psasir.upm.edu.my/id/eprint/77977/1/77977.pdf
http://psasir.upm.edu.my/id/eprint/77977/
https://www.mdpi.com/1424-8220/12/7/9603
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spelling my.upm.eprints.779772020-06-01T03:00:59Z http://psasir.upm.edu.my/id/eprint/77977/ Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system Yam, Mun Fei Ahmad, Mariam Por, Lip Yee Ang, Lee Fung Basir, Rusliza Asmawi, Mohd Zaini The stepping forces of normal and Freund Complete Adjuvant (FCA)-induced arthritic rats were studied in vivo using a proposed novel analgesic meter. An infrared charge-coupled device (CCD) camera and a data acquisition system were incorporated into the analgesic meter to determine and measure the weight of loads on the right hind paw before and after induction of arthritis by FCA injection into the paw cavity. FCA injection resulted in a significant reduction in the stepping force of the affected hind paw. The stepping force decreased to the minimum level on day 4 after the injection and then gradually increased up to day 25. Oral administration of prednisolone significantly increased the stepping forces of FCA-induced arthritic rats on days 14 and 21. These results suggest that the novel device is an effective tool for measuring the arthritic pain in in vivo studies even though walking is a dynamic condition. MDPI 2012 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77977/1/77977.pdf Yam, Mun Fei and Ahmad, Mariam and Por, Lip Yee and Ang, Lee Fung and Basir, Rusliza and Asmawi, Mohd Zaini (2012) Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system. Sensors, 12 (7). pp. 9603-9612. ISSN 1424-8220 https://www.mdpi.com/1424-8220/12/7/9603 10.3390/s120709603
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The stepping forces of normal and Freund Complete Adjuvant (FCA)-induced arthritic rats were studied in vivo using a proposed novel analgesic meter. An infrared charge-coupled device (CCD) camera and a data acquisition system were incorporated into the analgesic meter to determine and measure the weight of loads on the right hind paw before and after induction of arthritis by FCA injection into the paw cavity. FCA injection resulted in a significant reduction in the stepping force of the affected hind paw. The stepping force decreased to the minimum level on day 4 after the injection and then gradually increased up to day 25. Oral administration of prednisolone significantly increased the stepping forces of FCA-induced arthritic rats on days 14 and 21. These results suggest that the novel device is an effective tool for measuring the arthritic pain in in vivo studies even though walking is a dynamic condition.
format Article
author Yam, Mun Fei
Ahmad, Mariam
Por, Lip Yee
Ang, Lee Fung
Basir, Rusliza
Asmawi, Mohd Zaini
spellingShingle Yam, Mun Fei
Ahmad, Mariam
Por, Lip Yee
Ang, Lee Fung
Basir, Rusliza
Asmawi, Mohd Zaini
Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system
author_facet Yam, Mun Fei
Ahmad, Mariam
Por, Lip Yee
Ang, Lee Fung
Basir, Rusliza
Asmawi, Mohd Zaini
author_sort Yam, Mun Fei
title Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system
title_short Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system
title_full Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system
title_fullStr Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system
title_full_unstemmed Screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system
title_sort screening of stepping forces in an arthritic rat model using a novel analgesic meter and data acquisition system
publisher MDPI
publishDate 2012
url http://psasir.upm.edu.my/id/eprint/77977/1/77977.pdf
http://psasir.upm.edu.my/id/eprint/77977/
https://www.mdpi.com/1424-8220/12/7/9603
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score 13.214268