Palladium and copper catalyzed Sonogashira cross coupling has been an excellent methodology for C-C bond formation for 17 years: a review

• Main Authors: Kanwal, Iram, Mujahid, Aqsa, Rasool, Nasir, Rizwan, Komal, Malik, Ayesha, Ahmad, Gulraiz, Shah, Syed Adnan Ali, Rashid, Umer, Mad Nasir, Nadiah
• Format: Article
• Language: English
• Published: MDPI 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/77749/1/77749.pdf; http://psasir.upm.edu.my/id/eprint/77749/; https://www.mdpi.com/2073-4344/10/4/443

Sonogashira coupling involves coupling of vinyl/aryl halides with terminal acetylenes catalyzed by transition metals, especially palladium and copper. This is a well known reaction in organic synthesis and plays a role in sp2-sp C-C bond formations. This cross coupling was used in synthesis of natur...