Computational design of artificial metallo-haloalkane dehalogenase

• Main Authors: Ang, Thiau Fu, Mohd Yahaya, Normi, Salleh, Abu Bakar, Leow, Adam Thean Chor
• Format: Conference or Workshop Item
• Language: English
• Published: 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/75677/1/Computational%20design%20of%20artificial%20metallo-haloalkane%20dehalogenase.pdf; http://psasir.upm.edu.my/id/eprint/75677/

Haloalkane dehalogenases (HLDs) can catalyze conversion of some toxic haloalkanes to corresponding harmless alcohols. The limiting factors of native HLDs are their slow product releasing step, low activity against non-natural substrates and synthetic substrates. By creating an artificial metallo-HLD...