In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens

• Main Authors: Wee, Allan Ren Ng, Tan, Pei Jun, Pui, Winfrey Yee Hoo, Liew, Dek Shen, Yee, Michelle Mun Teo, Pui, Yan Siak, Ng, Sze Man, Tan, Ee Wern, Abdul Rahim, Raha, Lay, Renee Hong Lim, Ai, Adelene Lian Song, Lian, Lionel Aun In
• Format: Article
• Language: English
• Published: PeerJ 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/74613/1/In%20silico-guided%20sequence%20modifications%20of%20K-ras%20epitopes%20improve%20immunological%20outcome%20against%20G12V%20and%20G13D%20mutant%20KRAS%20antigens.pdf; http://psasir.upm.edu.my/id/eprint/74613/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055689/

Background: Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts are non-responsive to anti-EGFR treatments,...