Synthesis and in vitro antiproliferative activity of new 1-phenyl-3-(4-(pyridin-3-yl)phenyl)urea scaffold-based compounds

• Main Authors: Al-Sanea, Mohammad M., Ali Khan, Mohammed Safwan, Abdelazem, Ahmed Z., Lee, So Ha, Mok, Pooi Ling, Gamal, Mohammed, Shaker, Mohamed E., Afzal, Muhammad, Youssif, Bahaa G. M., Omar, Nesreen Nabil
• Format: Article
• Language: English
• Published: MDPI 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/74054/1/Synthesis%20and%20In%20vitro%20antiproliferative%20activity%20of%20new%201-phenyl-3-%284-%28pyridin-3-yl%29phenyl%29urea%20scaffold-based%20compounds.pdf; http://psasir.upm.edu.my/id/eprint/74054/

A new series of 1-phenyl-3-(4-(pyridin-3-yl)phenyl)urea derivatives were synthesized and subjected to in vitro antiproliferative screening against National Cancer Institute (NCI)-60 human cancer cell lines of nine different cancer types. Fourteen compounds 5a-n were synthesized with three different...