Cisplatin encapsulation generates morphologically different multicompartments in the internal nanostructures of nonlamellar liquid-crystalline self-assemblies

• Main Authors: Mat Azmi, Intan Diana, Yaghmur, Anan, Ostergaard, Jesper, Sturup, Stefan, Gammelgaard, Bente, Urtti, Arto, Moghimi, Moein
• Format: Article
• Language: English
• Published: American Chemical Society 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/73399/1/CISP.pdf; http://psasir.upm.edu.my/id/eprint/73399/; https://pubs.acs.org/doi/full/10.1021/acs.langmuir.8b01149

Cisplatin (cis-diamminedichloroplatinum(II)) is among the most potent cytotoxic agents used in cancer chemotherapy. The encapsulation of cisplatin in lipid-based drug carriers has been challenging owing to its low solubility in both aqueous and lipid phases. Here, we investigated cisplatin encapsula...