Factors affecting nucleolytic efficiency of some ternary metal complexes with DNA binding and recognition domains. Crystal and molecular structure of Zn(phen)(edda)

• Main Authors: Seng, Hoi Ling, Ong, Alan Han Kiat, Raja Abdul Rahman, Raja Noor Zaliha, Mohd Yamin, Bohari, Tiekink, Edward R. T., Tan, Kong Wai, Maah, Mohd Jamil, Caracelli, Ignez, Ng, Chew Hee
• Format: Article
• Language: English
• Published: Elsevier 2008
• Online Access: http://psasir.upm.edu.my/id/eprint/7325/1/Factors%20affecting%20nucleolytic%20efficiency%20of%20some%20ternary%20metal%20complexes%20with%20DNA%20binding%20and%20recognition%20domains.%20Crystal%20and%20molecular%20structure%20of%20Zn%28phen%29%28edda%29.pdf; http://psasir.upm.edu.my/id/eprint/7325/; http://www.sciencedirect.com/science/article/pii/S0162013408001803

The binding selectivity of the M(phen)(edda) (M = Cu, Co, Ni, Zn; phen = 1,10-phenanthroline, edda = ethylenediaminediacetic acid) complexes towards ds(CG)6, ds(AT)6 and ds(CGCGAATTCGCG) B-form oligonucleotide duplexes were studied by CD spectroscopy and molecular modeling. The binding mode is inter...