Excipient selection and aerodynamic characterization of nebulized lipid-based nanoemulsion loaded with docetaxel for lung cancer treatment

• Main Authors: Asmawi, Azren Aida, Salim, Norazlinaliza, Ngan, Cheng Loong, Ahmad, Haslina, Abd. Malek, Emilia, Masarudin, Mas Jaffri, Abdul Rahman, Mohd Basyaruddin
• Format: Article
• Language: English
• Published: Springer 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/72659/1/Excipient%20selection%20and%20aerodynamic%20characterization.pdf; http://psasir.upm.edu.my/id/eprint/72659/; https://link.springer.com/article/10.1007/s13346-018-0526-4#citeas

Docetaxel has demonstrated extraordinary anticancer effects on lung cancer. However, lack of optimal bioavailability due to poor solubility and high toxicity at its therapeutic dose has hampered the clinical use of this anticancer drug. Development of nanoemulsion formulation along with biocompatibl...