Curcumin analog DK1 induces apoptosis in human osteosarcoma cells in vitro through mitochondria-dependent signaling pathway

• Main Authors: Aziz, Muhammad Nazirul Mubin, Hussin, Yazmin, Che Rahim, Nurul Fattin, Nordin, Noraini, Mohamad, Nurul Elyani, Yeap, Swee Keong, Yong, Chean Yeah, Masarudin, Mas Jaffri, Cheah, Yoke Kqueen, Abu, Nadiah, Akhtar, Muhammad Nadeem, Mohammed Alitheen, Noorjahan Banu
• Format: Article
• Language: English
• Published: M D P I AG 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/72154/1/Curcumin%20analog%20DK1%20induces%20apoptosis%20in%20human%20osteosarcoma%20cells%20in%20vitro%20through%20mitochondria-dependent%20signaling%20pathway.pdf; http://psasir.upm.edu.my/id/eprint/72154/; https://www.mdpi.com/1420-3049/23/1/75

Osteosarcoma is one of the primary malignant bone tumors that confer low survival rates for patients even with intensive regime treatments. Therefore, discovery of novel anti-osteosarcoma drugs derived from natural products that are not harmful to the normal cells remains crucial. Curcumin is one of...