Critical roles of IL-33/ST2 pathway in neurological disorders

• Main Authors: Abd Rachman Isnadi, Mohammad Faruq, Chin, Voon Kin, Abd. Majid, Roslaini, Lee, Tze Yan, Abdullah, Maizaton Atmadini, Omenesa, Ramatu Bello, Ibraheem, Zaid Osamah, Basir, Rusliza
• Format: Article
• Language: English
• Published: Hindawi 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/72141/1/neurological%20disorders.pdf; http://psasir.upm.edu.my/id/eprint/72141/; https://www.hindawi.com/journals/mi/2018/5346413/

Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors, mainly with ST2 variants. IL-33 is a potent inducer for the Th2 immune response which includes defence mechanism in brain diseases. Thus, in this paper, we review the biological features of IL-33 and the critical roles of IL-33/ST2 pathway in selected neurological disorders including Alzheimer’s disease, multiple sclerosis, and malaria infection to discuss the involvement of IL-33/ST2 pathway during these brain diseases and its potential as future immunotherapeutic agents or for intervention purposes.