Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control...
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Online Journal of Veterinary Research
2009
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Online Access: | http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf http://psasir.upm.edu.my/id/eprint/7064/ http://onljvetres.com/pasteurellaabs2009.htm |
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my.upm.eprints.70642016-11-22T01:09:45Z http://psasir.upm.edu.my/id/eprint/7064/ Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. Online Journal of Veterinary Research 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf Khin, Myat Nwe and Saad, Mohd Zamri and Mohamed Mustapha, Noordin and Abd Wahid, Mohd Effendy (2009) Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves. Online Journal of Veterinary Research, 13 (2). pp. 65-72. ISSN 1328-925X http://onljvetres.com/pasteurellaabs2009.htm |
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This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. |
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Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy |
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Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
author_facet |
Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy |
author_sort |
Khin, Myat Nwe |
title |
Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_short |
Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_full |
Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_fullStr |
Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_full_unstemmed |
Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_sort |
effect of intranasal attenuated pasteurella multocida b:2 on haemorrhagic septicaemia in calves |
publisher |
Online Journal of Veterinary Research |
publishDate |
2009 |
url |
http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf http://psasir.upm.edu.my/id/eprint/7064/ http://onljvetres.com/pasteurellaabs2009.htm |
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1643823612399976448 |
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13.18916 |