Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Springer Wien
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/693/1/PFBSB7.pdf http://psasir.upm.edu.my/id/eprint/693/ http://dx.doi.org/10.1007/s00705-004-0336-5 |
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| Summary: | Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation this does not correlate with the pathogenicity of the viral strains but is may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses. |
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