Antimicrobial susceptibility of Leptospira spp. isolated from environmental, human and animal sources in Malaysia

• Main Authors: Benacer, Douadi, Mohd Zain, Siti Nursheena, Peck, Toung Ooi, Kwai, Lin Thong
• Format: Article
• Language: English
• Published: Medknow Publications 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/60888/1/Antimicrobial%20susceptibility%20of%20Leptospira%20spp.%20isolated%20from%20environmental%2C%20human%20and%20animal%20sources%20in%20Malaysia.pdf; http://psasir.upm.edu.my/id/eprint/60888/; http://eprints.um.edu.my/18382/1/Antimicrobial_Susceptibility_of_Leptospira_spp._Isolated_from.pdf

Leptospirosis is a zoonosis with worldwide distribution caused by pathogenic spirochetes of the genus Leptospira. The aim of this study was to evaluate the susceptibility of isolates obtained from different hosts. A total of 65 Leptospira isolates from humans (n = 1), zoonoses (rat, n = 60; dog, n = 1; swine, n = 1) and environment (n = 2) were tested against six antibiotics. All the isolates were resistant to trimethoprim and sulphamethoxazole and had high MIC toward chloramphenicol (MIC90: 6.25 μg/ml). All except one environment isolate were sensitive to ampicillin, doxycycline and penicillin G.