Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice

• Main Authors: Mitutsova, Violeta, Wai, Wendy Yeng Yeo, Davaze, Romain, Franckhauser, Celine, El-Habib, Hani, Abdullah, Syahril, Mollard, Patrice, Schaeffer, Marie, Fernandez, Anne, Lamb, Ned J. C.
• Format: Article
• Language: English
• Published: BioMed Central 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/60780/1/Adult%20muscle-derived%20stem%20cells%20engraft%20and%20differentiate%20into%20insulin-expressing%20cells%20in%20pancreatic%20islets%20of%20diabetic%20mice.pdf; http://psasir.upm.edu.my/id/eprint/60780/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395782/pdf/13287_2017_Article_539.pdf

BACKGROUND: Pancreatic beta cells are unique effectors in the control of glucose homeostasis and their deficiency results in impaired insulin production leading to severe diabetic diseases. Here, we investigated the potential of a population of nonadherent muscle-derived stem cells (MDSC) from adult...