Does high public health expenditure slow down economic growth?
The Fritillaria imperialis is an ornamental flower that can be found in various parts of the world including Iraq, Afghanistan, Pakistan, and the Himalayas. The use of this plant as traditional remedy is widely known. This study aims to unveil the anti-cancer potentials of Isopimara-7,15-Dien-19-Oic...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
ASERS Publishing
2016
|
Online Access: | http://psasir.upm.edu.my/id/eprint/55560/1/Does%20high%20public%20health%20expenditure%20slow%20down%20economic%20growth.docx.pdf http://psasir.upm.edu.my/id/eprint/55560/ https://www.ceeol.com/search/article-detail?id=535511 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.upm.eprints.55560 |
---|---|
record_format |
eprints |
spelling |
my.upm.eprints.555602017-08-14T10:03:15Z http://psasir.upm.edu.my/id/eprint/55560/ Does high public health expenditure slow down economic growth? Sirag, Abdalla Mohamed Nor, Norashidah Raja Abdullah, Nik Mustapha Karimi, Mohammad The Fritillaria imperialis is an ornamental flower that can be found in various parts of the world including Iraq, Afghanistan, Pakistan, and the Himalayas. The use of this plant as traditional remedy is widely known. This study aims to unveil the anti-cancer potentials of Isopimara-7,15-Dien-19-Oic Acid, extracted from the bulbs of F. imperialis in cervical cancer cell line, HeLa cells. Flow cytometry analysis of cell death, gene expression analysis via cDNA microarray and protein array were performed. Based on the results, Isopimara-7,15-Dien-19-Oic acid simultaneously induced cell death and promoted cell survival. The execution of apoptosis was apparent based on the flow cytometry results and regulation of both pro and anti-apoptotic genes. Additionally, the regulation of anti-oxidant genes were up-regulated especially thioredoxin, glutathione and superoxide dismutase- related genes. Moreover, the treatment also induced the activation of pro-survival heat shock proteins. Collectively, Isopimara-7,15-Dien-19-Oic Acid managed to induce cellular stress in HeLa cells and activate several anti- and pro survival pathways. ASERS Publishing 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55560/1/Does%20high%20public%20health%20expenditure%20slow%20down%20economic%20growth.docx.pdf Sirag, Abdalla and Mohamed Nor, Norashidah and Raja Abdullah, Nik Mustapha and Karimi, Mohammad (2016) Does high public health expenditure slow down economic growth? Journal of Applied Economic Sciences, 11 (1(39)). pp. 5-17. ISSN 1843-6110 https://www.ceeol.com/search/article-detail?id=535511 |
institution |
Universiti Putra Malaysia |
building |
UPM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Putra Malaysia |
content_source |
UPM Institutional Repository |
url_provider |
http://psasir.upm.edu.my/ |
language |
English |
description |
The Fritillaria imperialis is an ornamental flower that can be found in various parts of the world including Iraq, Afghanistan, Pakistan, and the Himalayas. The use of this plant as traditional remedy is widely known. This study aims to unveil the anti-cancer potentials of Isopimara-7,15-Dien-19-Oic Acid, extracted from the bulbs of F. imperialis in cervical cancer cell line, HeLa cells. Flow cytometry analysis of cell death, gene expression analysis via cDNA microarray and protein array were performed. Based on the results, Isopimara-7,15-Dien-19-Oic acid simultaneously induced cell death and promoted cell survival. The execution of apoptosis was apparent based on the flow cytometry results and regulation of both pro and anti-apoptotic genes. Additionally, the regulation of anti-oxidant genes were up-regulated especially thioredoxin, glutathione and superoxide dismutase- related genes. Moreover, the treatment also induced the activation of pro-survival heat shock proteins. Collectively, Isopimara-7,15-Dien-19-Oic Acid managed to induce cellular stress in HeLa cells and activate several anti- and pro survival pathways. |
format |
Article |
author |
Sirag, Abdalla Mohamed Nor, Norashidah Raja Abdullah, Nik Mustapha Karimi, Mohammad |
spellingShingle |
Sirag, Abdalla Mohamed Nor, Norashidah Raja Abdullah, Nik Mustapha Karimi, Mohammad Does high public health expenditure slow down economic growth? |
author_facet |
Sirag, Abdalla Mohamed Nor, Norashidah Raja Abdullah, Nik Mustapha Karimi, Mohammad |
author_sort |
Sirag, Abdalla |
title |
Does high public health expenditure slow down economic growth? |
title_short |
Does high public health expenditure slow down economic growth? |
title_full |
Does high public health expenditure slow down economic growth? |
title_fullStr |
Does high public health expenditure slow down economic growth? |
title_full_unstemmed |
Does high public health expenditure slow down economic growth? |
title_sort |
does high public health expenditure slow down economic growth? |
publisher |
ASERS Publishing |
publishDate |
2016 |
url |
http://psasir.upm.edu.my/id/eprint/55560/1/Does%20high%20public%20health%20expenditure%20slow%20down%20economic%20growth.docx.pdf http://psasir.upm.edu.my/id/eprint/55560/ https://www.ceeol.com/search/article-detail?id=535511 |
_version_ |
1643835931406368768 |
score |
13.18916 |