CYP2D6 genetic polymorphisms and phenotypes in different ethnicities of Malaysian breast cancer patients

• Main Authors: Fee, Wai Chin, Soon, Choy Chan, Abdul Rahman, Sabariah, , Sharifah Noor Akmal, Rosli, Rozita
• Format: Article
• Language: English
• Published: John Wiley & Sons 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/55412/1/CYP2D6%20genetic%20polymorphisms%20and%20phenotypes%20in%20different%20ethnicities%20of%20Malaysian%20breast%20cancer%20patients.pdf; http://psasir.upm.edu.my/id/eprint/55412/

The cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) is an enzyme that is predominantly involved in the metabolism of tamoxifen. Genetic polymorphisms of the CYP2D6 gene may contribute to inter-individual variability in tamoxifen metabolism, which leads to the differences in clinical r...