Animal model of gestational diabetes mellitus with pathophysiological resemblance to the human condition induced by multiple factors (nutritional, pharmacological, and stress) in rats

• Main Authors: Abdul Aziz, Siti Hajar, John, Cini Mathew, Mohamed Yusof, Nur Intan Saidaah, Nordin, Massita, Ramasamy, Rajesh, Adam, Aishah, Mohd Fauzi, Fazlin
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/55066/1/Animal%20Model%20of%20Gestational%20Diabetes%20Mellitus.pdf; http://psasir.upm.edu.my/id/eprint/55066/

This study attempts to develop an experimental gestational diabetes mellitus (GDM) animal model in female Sprague-Dawley rats. Rats were fed with high fat sucrose diet, impregnated, and induced with Streptozotocin and Nicotinamide on gestational day 0 (D0). Sleeping patterns of the rats were also ma...