Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

• Main Authors: Merlot, Angelica M., Shafie, Nurul Husna, Yu, Yu, Richardson, Vera, Jansson, Patric J., Sahni, Sumit, Lane, Darius J. R., Kovacevic, Zaklina, Kalinowski, Danuta S., Richardson, Des R.
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/54771/1/Mechanism%20of%20the%20induction%20of%20endoplasmic%20reticulum%20stress%20by%20the%20anti-cancer%20agent.pdf; http://psasir.upm.edu.my/id/eprint/54771/; https://www.sciencedirect.com/science/article/pii/S0006295216300235?via%3Dihub#!

The endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of proteins and is a critical calcium (Ca2+) reservoir. Cellular stresses lead to an overwhelming accumulation of misfolded proteins in the ER, leading to ER stress and the activation of the unfolded protein r...