Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor‐related apoptosis‐inducing ligand

• Main Authors: Harith, Hanis Hazeera, Di Bartolo, Belinda A., Cartland, Sian P., Genner, Scott, Kavurma, Mary M.
• Format: Article
• Language: English
• Published: Wiley-Blackwell Publishing 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/54583/1/Insulin%20promotes%20vascular%20smooth%20muscle%20cell%20proliferation.pdf; http://psasir.upm.edu.my/id/eprint/54583/; https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12339

Background: Insulin regulates glucose homeostasis but can also promote vascular smooth muscle (VSMC) proliferation, important in atherogenesis. Recently, we showed that tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) stimulates intimal thickening via accelerated growth of VSMCs. The...