Negative chromatography of hepatitis B virus-like particles: comparative study of different adsorbent designs

• Main Authors: Lee, Micky Fu Xiang, Chan, Eng Seng, Tan, Wen Siang, Tam, Kam Chiu, Tey, Beng Ti
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/53368/1/Negative%20chromatography%20of%20hepatitis%20B%20virus-like%20particles%20comparative%20study%20of%20different%20adsorbent%20designs.pdf; http://psasir.upm.edu.my/id/eprint/53368/; https://www.sciencedirect.com/science/article/pii/S002196731630348X?via%3Dihub

Purification of virus-like particles (VLPs) in bind-and-elute mode has reached a bottleneck. Negative chromatography has emerged as the alternative solution; however, benchmark of negative chromatography media and their respective optimized conditions are absent. Hence, this study was carried out to...