The effect of water deprivation on the pharmacokinetics of antipyrine and sulphadimidine following intravenous administration in Nubian goats

• Main Authors: Elsheikh, Hatim Ali, Osman, I. A. M., Abdullah, A. S.
• Format: Article
• Language: English; English
• Published: Kluwer Academic Publishers 1997
• Online Access: http://psasir.upm.edu.my/id/eprint/51050/1/The%20effect%20of%20water%20deprivation%20on%20the%20pharmacokinetics%20of%20antipyrine%20and%20sulphadimidine%20following%20intravenous%20administration%20in%20Nubian%20goats.pdf; http://psasir.upm.edu.my/id/eprint/51050/7/A_1005975016275.pdf; http://psasir.upm.edu.my/id/eprint/51050/; http://link.springer.com/article/10.1023%2FA%3A1005975016275

The effect of water deprivation on the pharmacokinetic parameters of antipyrine and sulphadimidine in the Nubian goat was studied. Water deprivation, to a level of dehydration at which the animals lost an average of 7.5% body weight, resulted in a significant reduction in antipyrine clearance (p <...