Early signs of impaired renal function due to low grade subchronic lead intoxication in rats
Chronic high lead intoxication has been known to cause anaemia, nephropathy, gastrointestinal colic and neuropathy. Lead can be absorbed through the gastrointestinal and respiratory tract before being excreted through the kidneys. This study focuses on the early signs of impaired renal function in r...
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my.upm.eprints.502582017-03-01T09:39:15Z http://psasir.upm.edu.my/id/eprint/50258/ Early signs of impaired renal function due to low grade subchronic lead intoxication in rats Mohd Zairi, Nurul Huda Hamzah, Hazilawati Mohamed Mustapha, Noordin Shaari, Mohd Rosly Sithambaram, Shanmugavelu Haron, Nursyuhada Chronic high lead intoxication has been known to cause anaemia, nephropathy, gastrointestinal colic and neuropathy. Lead can be absorbed through the gastrointestinal and respiratory tract before being excreted through the kidneys. This study focuses on the early signs of impaired renal function in rats subjected to low grade lead toxicity through drinking water over a period of 12 weeks. Feed and water consumption were monitored during the course of the experiment, and the body weight were measured weekly. At the end of the stipulated time period, the rats were placed in individual metabolic cages for urine collection. Then, blood was collected via intracardiac puncture under general anaesthesia for haematology and plasma biochemistry evaluation. Finally, the rats were euthanized humanely to enable organ collection. Results showed no significant difference between body weight and water consumption, no clinical signs of anaemia, normal kidney parameters (blood urea nitrogen and creatinine) with significant increase (p<0.05) in blood potassium levels. Urinalysis revealed increased urine protein to creatinine ratio. There was also a significant decrease (p<0.05) in the kidney relative organ ratio between the group receiving 100 ppm lead (II) acetate daily and the control group. In conclusion, low grade subchronic lead intoxication indicates early signs of impaired renal function in rats which may lead to nephropathy. 2012 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/50258/1/2-29.pdf Mohd Zairi, Nurul Huda and Hamzah, Hazilawati and Mohamed Mustapha, Noordin and Shaari, Mohd Rosly and Sithambaram, Shanmugavelu and Haron, Nursyuhada (2012) Early signs of impaired renal function due to low grade subchronic lead intoxication in rats. In: International Conference on One Health and 24th VAM Congress 2012, 21-23 Sept. 2012, Marriott Putrajaya. (pp. 435-437). |
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Chronic high lead intoxication has been known to cause anaemia, nephropathy, gastrointestinal colic and neuropathy. Lead can be absorbed through the gastrointestinal and respiratory tract before being excreted through the kidneys. This study focuses on the early signs of impaired renal function in rats subjected to low grade lead toxicity through drinking water over a period of 12 weeks. Feed and water consumption were monitored during the course of the experiment, and the body weight were measured weekly. At the end of the stipulated time period, the rats were placed in individual metabolic cages for urine collection. Then, blood was collected via intracardiac puncture under general anaesthesia for haematology and plasma biochemistry evaluation. Finally, the rats were euthanized humanely to enable organ collection. Results showed no significant difference between body weight and water consumption, no clinical signs of anaemia, normal kidney parameters (blood urea nitrogen and creatinine) with significant increase (p<0.05) in blood potassium levels. Urinalysis revealed increased urine protein to creatinine ratio. There was also a significant decrease (p<0.05) in the kidney relative organ ratio between the group receiving 100 ppm lead (II) acetate daily and the control group. In conclusion, low grade subchronic lead intoxication indicates early signs of impaired renal function in rats which may lead to nephropathy. |
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Conference or Workshop Item |
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Mohd Zairi, Nurul Huda Hamzah, Hazilawati Mohamed Mustapha, Noordin Shaari, Mohd Rosly Sithambaram, Shanmugavelu Haron, Nursyuhada |
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Mohd Zairi, Nurul Huda Hamzah, Hazilawati Mohamed Mustapha, Noordin Shaari, Mohd Rosly Sithambaram, Shanmugavelu Haron, Nursyuhada Early signs of impaired renal function due to low grade subchronic lead intoxication in rats |
author_facet |
Mohd Zairi, Nurul Huda Hamzah, Hazilawati Mohamed Mustapha, Noordin Shaari, Mohd Rosly Sithambaram, Shanmugavelu Haron, Nursyuhada |
author_sort |
Mohd Zairi, Nurul Huda |
title |
Early signs of impaired renal function due to low grade subchronic lead intoxication in rats |
title_short |
Early signs of impaired renal function due to low grade subchronic lead intoxication in rats |
title_full |
Early signs of impaired renal function due to low grade subchronic lead intoxication in rats |
title_fullStr |
Early signs of impaired renal function due to low grade subchronic lead intoxication in rats |
title_full_unstemmed |
Early signs of impaired renal function due to low grade subchronic lead intoxication in rats |
title_sort |
early signs of impaired renal function due to low grade subchronic lead intoxication in rats |
publishDate |
2012 |
url |
http://psasir.upm.edu.my/id/eprint/50258/1/2-29.pdf http://psasir.upm.edu.my/id/eprint/50258/ |
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