Cofactor strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase

• Main Authors: Maniam, Sandra, Coutts, Amanda S., Stratford, Michael R. L., McGouran, Joanna F., Kessler, Benedikit M., La Thangue, N. B.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/44087/1/Cofactor%20strap%20regulates%20oxidative%20phosphorylation%20and%20mitochondrial%20p53%20activity%20through%20ATP%20synthase.pdf; http://psasir.upm.edu.my/id/eprint/44087/; https://www.nature.com/articles/cdd2014135

Metabolic reprogramming is a hallmark of cancer cells. Strap (stress-responsive activator of p300) is a novel TPR motif OB-fold protein that contributes to p53 transcriptional activation. We show here that, in addition to its established transcriptional role, Strap is localised at mitochondria where...