Bixa orellana leaf extract suppress histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascade

• Main Authors: Yong, Yoke Keong, Abdullah, Muhammad Nazrul Hakim, Ahmad, Zuraini
• Format: Article
• Language: English
• Published: BMC 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/43955/1/Bixa%20orellana%20leaf%20extract%20suppress%20histamine-induced%20endothelial%20hyperpermeability%20via%20the%20PLC-NO-cGMP%20signaling%20cascade.pdf; http://psasir.upm.edu.my/id/eprint/43955/; https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-015-0901-3

Background: Histamine is established as a potent inflammatory mediator and it is known to increased endothelial permeability by promoting gap formation between endothelial cells. Previous studies have shown that aqueous extract of Bixa orellana leaves (AEBO) exhibits antihistamine activity in vivo,...