Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

• Main Authors: Hu, Zhiwei, Brooks, Samira A., Dormoy, Valérian, Hsu, Chia Wen, Hsu, Hsue Yin, Lin, Liang Tzung, Massfelder, Thierry, Rathmell, W. Kimryn, Xia, Menghang, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Prudhomme, Kalan R., Colacci, Anna Maria, Abd Hamid @ Abdul Razak, Roslida, Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Lowe, Leroy, Jensen, Lasse, Bisson, William H., Kleinstreuer, Nicole
• Format: Article
• Language: English
• Published: Oxford University Press 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/43846/1/Assessing%20the%20carcinogenic%20potential%20of%20low-dose%20exposures%20to%20chemical%20mixtures%20in%20the%20environment%20focus%20on%20the%20cancer%20hallmark%20of%20tumor%20angiogenesis.pdf; http://psasir.upm.edu.my/id/eprint/43846/; http://carcin.oxfordjournals.org/content/36/Suppl_1/S184.abstract

One of the important ‘hallmarks’ of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors...