Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri
Structure-activity relationships of eleven xanthones were comparatively predicted for four cancer cell lines after the compounds were subjected to antiproliferative assay against B-lymphocyte cells (Raji), colon carcinoma cells (LS174T), human neuroblastoma cells (IMR-32) and skin carcinoma cells (S...
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University of Karachi. Faculty of Pharmacy
2015
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my.upm.eprints.438052016-09-21T04:54:40Z http://psasir.upm.edu.my/id/eprint/43805/ Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri Siau, Hui Mah Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah Structure-activity relationships of eleven xanthones were comparatively predicted for four cancer cell lines after the compounds were subjected to antiproliferative assay against B-lymphocyte cells (Raji), colon carcinoma cells (LS174T), human neuroblastoma cells (IMR-32) and skin carcinoma cells (SK-MEL-28). The eleven chemical constituents were obtained naturally from the stem bark of Calophyllum inophyllum and Calophyllum soulattri. Inophinnin (1) and inophinone (2) were isolated from Calophyllum inophyllum while soulattrin (3) and phylattrin (4) were found from Calophyllum soulattri. The other xanthones were from both Calophyllum sp. and they are pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7), 4-hydroxyxanthone (8), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). Compound 3 was found to be the most cytotoxic towards all the cancer cell lines with an IC50 value of 1.25μg/mL while the simplest xanthone, compound 8 was inactive. University of Karachi. Faculty of Pharmacy 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43805/1/Antiproliferative%20xanthone%20derivatives%20from%20calophyllum%20inophyllum%20and%20calophyllum%20.pdf Siau, Hui Mah and Cheng, Gwendoline Lian Ee and Soek, Sin Teh and Sukari, Mohd Aspollah (2015) Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri. Pakistan Journal of Pharmaceutical Sciences, 28 (2). pp. 425-429. ISSN 1011-601X |
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Structure-activity relationships of eleven xanthones were comparatively predicted for four cancer cell lines after the compounds were subjected to antiproliferative assay against B-lymphocyte cells (Raji), colon carcinoma cells (LS174T), human neuroblastoma cells (IMR-32) and skin carcinoma cells (SK-MEL-28). The eleven chemical constituents were obtained naturally from the stem bark of Calophyllum inophyllum and Calophyllum soulattri. Inophinnin (1) and inophinone (2) were isolated from Calophyllum inophyllum while soulattrin (3) and phylattrin (4) were found from Calophyllum soulattri. The other xanthones were from both Calophyllum sp. and they are pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7), 4-hydroxyxanthone (8), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). Compound 3 was found to be the most cytotoxic towards all the cancer cell lines with an IC50 value of 1.25μg/mL while the simplest xanthone, compound 8 was inactive. |
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Siau, Hui Mah Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah |
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Siau, Hui Mah Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri |
author_facet |
Siau, Hui Mah Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah |
author_sort |
Siau, Hui Mah |
title |
Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri |
title_short |
Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri |
title_full |
Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri |
title_fullStr |
Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri |
title_full_unstemmed |
Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri |
title_sort |
antiproliferative xanthone derivatives from calophyllum inophyllum and calophyllum soulattri |
publisher |
University of Karachi. Faculty of Pharmacy |
publishDate |
2015 |
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http://psasir.upm.edu.my/id/eprint/43805/1/Antiproliferative%20xanthone%20derivatives%20from%20calophyllum%20inophyllum%20and%20calophyllum%20.pdf http://psasir.upm.edu.my/id/eprint/43805/ |
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13.18916 |