A comparison of assays for accurate copy number measurement of the low-affinity fc gamma receptor genes FCGR3A and FCGR3B

• Main Authors: Haridan, Umi Shakina, Mokhtar, Umairah, Machado, Lee R., Abdul Aziz, Abu Thalhah, Shomiad @ Shueb, Rafidah Hanim, Zaid, Masliza, Sim, Benedict, Mustafa, Mahiran, Nik Yusof, Nik Khairudin, Lee, Christopher K. C., Abu Bakar, Suhaili, Abu Bakar, Sazaly, Hollox, Edward J., Hoh, Boon Peng
• Format: Article
• Language: English
• Published: Public Library of Science 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/43474/1/A%20Comparison%20of%20Assays%20for%20Accurate%20Copy.PDF; http://psasir.upm.edu.my/id/eprint/43474/; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116791

The FCGR3 locus encoding the low affinity activating receptor FcγRIII, plays a vital role in immunity triggered by cellular effector and regulatory functions. Copy number of the genes FCGR3A and FCGR3B has previously been reported to affect susceptibility to several autoimmune diseases and chronic i...