Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations

• Main Authors: Ghabaee, Mojdeh, Omranisikaroudi, Motahar, Amrisaroukolaei, Shahla, Meysamie, Alipasha, Sahraian, Mohammad Ali, Bayati, Asghar, Sanati, Mohammad Hossein, Houshman, Mossoud, Sadeghian, Homa, Vajihazaman, Khalili
• Format: Article
• Language: English
• Published: Springer 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/40430/1/Mitochondrial%20mutation%20in%20iranian%20patients%20with%20multiple%20sclerosis%2C%20correlation%20between%20haplogroups%20H%2C%20A%20and%20clinical%20manifestations.pdf; http://psasir.upm.edu.my/id/eprint/40430/; http://link.springer.com/article/10.1007%2Fs10571-008-9325-7

As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirme...