Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica

• Main Authors: Ali, Abdul Manaf, Ismail, Nor Hadiani, Mohamed Mackeen, Muhammad Mukram, Saiful Yazan, Latifah, Mohamed, S. M., Ho, A. S. H., Lajis, Nordin
• Format: Article
• Language: English; English
• Published: Taylor & Francis 2000
• Online Access: http://psasir.upm.edu.my/id/eprint/40321/1/Antiviral%2C%20cyototoxic%20and%20antimicrobial%20activities%20of%20anthraquinones%20isolated%20from%20the%20roots%20of%20Morinda%20elliptica.pdf; http://psasir.upm.edu.my/id/eprint/40321/7/Antiviral%20%20Cyototoxic%20And%20Antimicrobial%20Activities%20Of%20Anthraquinones%20Isolated%20From%20The%20Roots%20Of%20Morinda%20Elliptica.pdf; http://psasir.upm.edu.my/id/eprint/40321/; http://www.tandfonline.com/doi/abs/10.1076/1388-0209%28200009%293841-AFT298#.VeZfV5drsZM

2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-?-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the roots of Morinda elliptica , were assayed for anti-HIV, cytotoxic and antimicrobial activites. Only damnacanthal showed moderate activity against HIV. It was cytotoxic towards the MCF-7 (breast carcinoma) and CEM-SS (T-lymphoblastic leukaemia) cell line. Nordamnacanthal was very cytotoxic against the CEM-SS cell lines. Other anthraquinones that showed strong cytotoxicity towards the cell lines tested were lucidin-?-methyl ether (CEM-SS and MCF-7) and rubiadin (CEM-SS). Three anthraquinones viz., nordamnacanthal, damnacanthal and morindone, were found to have strong antimicrobial activity.