Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac

• Main Authors: Rezaee, Malahat, Basri, Mahiran, Raja Abdul Rahman, Raja Noor Zaliha, Salleh, Abu Bakar, Chaibakhsh, Naz, Karjiban, Roghayeh Abedi
• Format: Article
• Language: English
• Published: Dove Medical Press 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/37709/1/Formulation%20development%20and%20optimization%20of%20palm%20kernel%20oil%20esters-based%20nanoemulsions%20containing%20sodium%20diclofenac.pdf; http://psasir.upm.edu.my/id/eprint/37709/; http://www.dovepress.com/formulation-development-and-optimization-of-palm-kernel-oil-esters-bas-peer-reviewed-article-IJN

Response surface methodology was employed to study the effect of formulation composition variables, water content (60%–80%, w/w) and oil and surfactant (O/S) ratio (0.17–1.33), as well as high-shear emulsification conditions, mixing rate (300–3,000 rpm) and mixing time (5–30 minutes) on the properti...