Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activation

• Main Authors: Abd Aziz, Noraini, Stanbridge, Eric J., Shafee, Norazizah
• Format: Article
• Language: English
• Published: Spandidos Publications 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/36675/1/Bortezomib%20attenuates%20HIF-1-%20but%20not%20HIF-2-mediated%20transcriptional%20activation.pdf; http://psasir.upm.edu.my/id/eprint/36675/; https://www.spandidos-publications.com/10.3892/ol.2015.3545/abstract

Bortezomib is the first proteasomal inhibitor (PI) to be used therapeutically for treating relapse cases of multiple myeloma and mantle cell lymphoma. A proposed mechanism for its action is that it prevents the proteasomal degradation of proapoptotic proteins, leading to enhanced apoptosis. Although...